Abstract
Conventional N-alkylation methods have been limited to approaches with high energy barriers and low selectivity. In this issue of Chem, MacMillan and co-workers report an innovative halogen abstraction-radical capture (HARC) strategy via metallaphotoredox catalysis that couples strained and hindered alkyl halides with a diverse range of N-nucleophiles.
Michael S. Crocker, Reem Nsouli, Laura K.G. Ackerman-Biegasiewicz, Reimagining C(sp3)–N bond formation via a HARC strategy, Chem, Volume 7, Issue 7, 2021, Pages 1688-1691, ISSN 2451-9294